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Rapamycin
Rapamycin
Feel and look younger with Rapamycin
Rapamycin (Sirolimus)
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What is Rapamycin?
Rapamycin (Sirolimus)is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
How does it work?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
- mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging. - Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
Benefits
✔ May extend lifespan and delay age-related disease
✔ Supports cellular autophagy and DNA repair
✔ Reduces chronic inflammation (“inflammaging”)
✔ Improves metabolic health and insulin sensitivity
✔ Works synergistically with fasting, exercise, and AMPK activators (e.g., Metformin)
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Frequently Asked Questions
Week 2–4:Subtle improvement in recovery, inflammation, skin tone
•Week 6–12:Better metabolic flexibility, energy, and clarity
•6–12 months:Long-term benefits on insulin sensitivity, lipid markers, and cellular health
• Optimal when combined withMetformin, exercise, time-restricted eating, NAD+ support
• Missed dose? Take on your next scheduled day—do not double dose
Common (Usually mild at low/intermittent doses):
• Mouth ulcers or canker sores
• Gastrointestinal discomfort
• Headache or fatigue
• Mild immunosuppression (dose-dependent)
Less Common / Monitor If Present:
• Elevated triglycerides or cholesterol
• Impaired wound healing
• Increased risk of infection at high doses
• Menstrual irregularities
